Branca M, Nicoletti L
Br J Cancer. 1977 Oct;36(4):487-92. doi: 10.1038/bjc.1977.218.
The effect of cyclophosphamide on MSV-H oncogensis and the immune response of young mice has been investigated. A single, sublethal dose (100 and 50 mg/kg of cyclophosphamide) in 8-day-old mice given 24 h before or after MSV-H infection led to an earlier and lower incidence of tumours in comparison with controls infected only with MSV-H. The protective effect of cyclophosphamide, and the mechanism of action of both cyclophosphamide and MSV-H on the target cells, mesenchymal cells in rapid replication, as well the immunological implications of the findings are discussed.
已经研究了环磷酰胺对MSV-H致癌作用以及幼鼠免疫反应的影响。在8日龄小鼠感染MSV-H之前或之后24小时给予单次亚致死剂量（100和50mg/kg环磷酰胺），与仅感染MSV-H的对照组相比，肿瘤的发生率更早且更低。讨论了环磷酰胺的保护作用，以及环磷酰胺和MSV-H对快速复制的靶细胞、间充质细胞的作用机制，以及这些发现的免疫学意义。
