Asbell Penny A, Spiegel Scott
Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York, USA.
Trans Am Ophthalmol Soc. 2009 Dec;107:205-10.
To understand ophthalmologists' current perceptions and treatment of patients with moderate to severe dry eye syndrome (DED).
An online survey was distributed to 7,882 ophthalmologists, including 51 corneal specialists, throughout the United States from October 9 to 21, 2008. The response rate was 3.1% (n = 245), typical for this type of survey. Those who treated 4 or more patients with moderate to severe DED per month (235 of 245 [96%]) were asked to complete the survey.
Ninety-four percent of respondents agreed that more treatment options are needed for moderate to severe DED. Corneal specialists were more likely to strongly agree (63%) than general ophthalmologists (54%). Only 33% overall felt that current therapies were extremely or very effective for moderate DED, and only 5% for severe disease. Ninety-two percent agreed that multiple therapeutic agents are needed to manage moderate to severe DED. The respondents reported prescribing, recommending, or suggesting a mean of 3.2 different treatment approaches over the course of a year for patients with moderate DED and 4.9 for patients with severe DED. The most highly ranked goals in treatment of moderate to severe DED were maintaining and protecting the ocular surface (ranked 1 or 2 by 74%) and lubricating and hydrating the ocular surface (ranked 1 or 2 by 67%). Corneal specialists ranked maintaining and protecting the ocular surface even higher (ranked 1 or 2 by 82%).
Results reflected the difficulty of treating more serious moderate to severe cases, the importance of using multiple treatment approaches, the limitations of current treatment options, and the need for additional treatment options.
了解眼科医生对中重度干眼综合征(DED)患者的当前认知及治疗情况。
2008年10月9日至21日,一项在线调查在美国7882名眼科医生中展开,其中包括51名角膜专科医生。回复率为3.1%(n = 245),这在这类调查中较为典型。要求那些每月治疗4例或更多中重度DED患者的医生(245名中的235名[96%])完成调查。
94%的受访者认为中重度DED需要更多的治疗选择。角膜专科医生比普通眼科医生更有可能强烈认同这一点(分别为63%和54%)。总体而言,只有33%的人认为当前疗法对中度DED极其或非常有效,对重度DED仅为5%。92%的人同意需要多种治疗药物来治疗中重度DED。受访者报告称,在一年中,他们为中度DED患者平均开出、推荐或建议3.2种不同的治疗方法,为重度DED患者平均开出4.9种。治疗中重度DED的最高目标是维持和保护眼表(74%的人将其排在第1或第2位)以及润滑和保湿眼表(67%的人将其排在第1或第2位)。角膜专科医生对维持和保护眼表的排名更高(82%的人将其排在第1或第2位)。
结果反映了治疗更严重的中重度病例的困难、采用多种治疗方法的重要性、当前治疗选择的局限性以及对更多治疗选择的需求。