Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Chem Commun (Camb). 2010 Feb 21;46(7):1118-20. doi: 10.1039/b919888a. Epub 2009 Dec 14.
Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.
已经开发出两种不同的策略，即基于二醛的交联和光亲和标记，用于生成针对 Abelson（Abl）酪氨酸激酶的小分子活性基探针（ABP），其中源自光亲和标记方法的探针 13 显示出对粗制哺乳动物蛋白质组中存在的 Abl 激酶的特异性标记。
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