一种针对 Abl 酪氨酸激酶活性构象的肽类光亲和探针。
A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.
机构信息
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Chembiochem. 2012 Nov 26;13(17):2510-2. doi: 10.1002/cbic.201200560. Epub 2012 Oct 18.
Abstract
The design of sensors to monitor the activity state of specific protein kinases is challenging due to the complexity of eukaryotic kinomes. Here we describe a peptide-based photaffinity probe that specifically labels the active conformation of the Abl tyrosine kinase.
摘要
由于真核激酶组的复杂性，设计用于监测特定蛋白激酶活性状态的传感器具有挑战性。在这里，我们描述了一种基于肽的光亲和探针，该探针特异性标记 Abl 酪氨酸激酶的活性构象。
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2
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J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
3
Targeting diverse signaling interaction sites allows the rapid generation of bivalent kinase inhibitors.
ACS Chem Biol. 2012 Mar 16;7(3):487-95. doi: 10.1021/cb200387g. Epub 2011 Dec 22.
4
In situ kinase profiling reveals functionally relevant properties of native kinases.
Chem Biol. 2011 Jun 24;18(6):699-710. doi: 10.1016/j.chembiol.2011.04.011.
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Anal Chem. 2011 Jan 1;83(1):52-9. doi: 10.1021/ac102786c. Epub 2010 Dec 3.
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Curr Opin Genet Dev. 2011 Feb;21(1):4-11. doi: 10.1016/j.gde.2010.10.012. Epub 2010 Nov 29.
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