Lazari Maria Fatima Magalhães, Lucas Thais Fabiana Gameiro, Yasuhara Fabiana, Gomes Gisele Renata Oliveira, Siu Erica Rosanna, Royer Carine, Fernandes Sheilla Alessandra Ferreira, Porto Catarina Segreti
Setor de Endocrinologia Experimental, Departamento de Farmacologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Arq Bras Endocrinol Metabol. 2009 Nov;53(8):923-33. doi: 10.1590/s0004-27302009000800005.
A substantial advance in our understanding on the estrogen signaling occurred in the last decade. Estrogens interact with two receptors, ESR1 and ESR2, also known as ERalpha and ERbeta, respectively. ESR1 and ESR2 belong to the nuclear receptor family of transcription factors. In addition to the well established transcriptional effects, estrogens can mediate rapid signaling, triggered within seconds or minutes. These rapid effects can be mediated by ESRs or the G protein-coupled estrogen receptor GPER, also known as GPR30. The effects of estrogen on cell proliferation, differentiation and apoptosis are often mediated by growth factors. The understanding of the cross-talk between androgen, estrogen and growth factors signaling pathways is therefore essential to understand the physiopathological mechanisms of estrogen action. In this review we focused on recent discoveries about the nature of the estrogen receptors, and on the signaling and function of estrogen in the male reproductive system.
在过去十年里，我们对雌激素信号传导的理解取得了重大进展。雌激素与两种受体相互作用，分别是ESR1和ESR2，也分别被称为ERα和ERβ。ESR1和ESR2属于转录因子的核受体家族。除了已确定的转录效应外，雌激素还能介导在数秒或数分钟内触发的快速信号传导。这些快速效应可由雌激素受体或G蛋白偶联雌激素受体GPER（也称为GPR30）介导。雌激素对细胞增殖、分化和凋亡的影响通常由生长因子介导。因此，了解雄激素、雌激素和生长因子信号通路之间的相互作用对于理解雌激素作用的生理病理机制至关重要。在这篇综述中，我们重点关注了关于雌激素受体性质的最新发现，以及雌激素在男性生殖系统中的信号传导和功能。
