Biondo-Simões Maria de Lourdes Pessole, Zammar Guilherme Roberto, Fernandes Rodrigo dos Santos, Biondo-Simões Rachel, Mello Flavia Stica Ritzdorf de, Noronha Lucia de
Scientific Methodology, PUCPR, Brazil.
Acta Cir Bras. 2010 Feb;25(1):86-92. doi: 10.1590/s0102-86502010000100018.
Treatment for obesity essentially has to do with weight loss, which can be achieved through surgical procedures. Despite the considerable rise in the number of such procedures, the relationship between obesity and the healing process has not been totally clarified.
To investigate abdominal wound healing in obese Wistar rats on the seventh and fourteenth days following a laparotomy.
Thirty-six Wistar rats were randomly distributed into two groups, the control and experiment group. The control group were fed on either a standard diet for the species and the experiment group were put on a high calorie diet. After 116 days, all the animals were submitted to a laparotomy followed by laparorrhaphy. After euthanasia on the seventh or fourteenth day, fragments of the abdominal wound containing the scar were submitted to histopathological and tensiometric analysis.
The average weight of the animals from the experiment group was higher than that of the control group (p<0.001). The difference in the resistance of the cutaneous scars was not significant. The aponeurotic scars were more resistant in the control group after seven days (p=0.011) and fourteen days (p=0.040). There was no difference in terms of intensity of the inflammatory reaction and the collagen density was similar in both groups.
In rats, obesity lowered the resistance of the aponeurotic scars but not the skin scars. It did not interfere with the delayed inflammatory response and the collagen density.
肥胖症的治疗主要涉及体重减轻，这可通过外科手术实现。尽管此类手术的数量大幅增加，但肥胖与愈合过程之间的关系尚未完全阐明。
研究肥胖的Wistar大鼠剖腹术后第7天和第14天腹部伤口的愈合情况。
将36只Wistar大鼠随机分为两组，即对照组和实验组。对照组给予该物种的标准饮食，实验组给予高热量饮食。116天后，所有动物均接受剖腹术及随后的腹壁缝合术。在第7天或第14天安乐死后，取含瘢痕的腹部伤口组织块进行组织病理学和张力测定分析。
实验组动物的平均体重高于对照组（p<0.001）。皮肤瘢痕的抗张强度差异不显著。对照组在术后7天（p=0.011）和14天（p=0.040）时腱膜瘢痕的抗张强度更高。两组的炎症反应强度无差异，胶原密度相似。
在大鼠中，肥胖降低了腱膜瘢痕的抗张强度，但未降低皮肤瘢痕的抗张强度。它不影响延迟性炎症反应和胶原密度。
