Graduate student. Centro Universitário do Estado do Pará - School of Medicine - Belém (PA), Brazil.
Fellow Master degree. Universidade do Estado do Pará - Surgery and Experimental Research - Belém (PA), Brazil.
Acta Cir Bras. 2023 Jan 6;37(10):e371006. doi: 10.1590/acb371006. eCollection 2023.
To analyze the effects of Anacardium occidentale Linn on the healing of skin wounds.
Twenty Wistar male rats were distributed into four groups (with five animals each one): negative control group (NCG), treated with saline solution; cashew tree group (CG), treated with hydroalcoholic extract of the bark of A. occidentale Linn; manipulated cashew tree group (MCG), with the ointment of extract of the bark of A. occidentale Linn; positive control group (PCG), treated with sunflower oil. All animals were examined daily, observing the macroscopic aspects of the surgical wound. Hematoxylin-eosin staining was used for tissue morphology analysis and Masson's trichrome for better collagen fiber characterization.
On day 7, the MCG group had the expansion of the surgical wound covered by crust, exceeding the initial limits. On day 21, the wounds were observed to be completely closed and epithelialized in the NCG and CG groups. PCG and MCG still had remnants of crusts on the wound. The NCG was the only one not to present an abscess in histopathological analysis.
There was a prolongation of the healing phase of the animals treated with the extract, and the animals in the NCG showed a better outcome by histological analysis.
分析植物漆树对皮肤创伤愈合的影响。
将 20 只雄性 Wistar 大鼠随机分为 4 组（每组 5 只）：阴性对照组（NCG），给予生理盐水；腰果组（CG），给予植物漆树树皮水醇提取物；手术处理腰果组（MCG），给予植物漆树树皮提取物软膏；阳性对照组（PCG），给予葵花籽油。所有动物每天进行检查，观察手术伤口的宏观表现。苏木精-伊红染色用于组织形态分析，马松三色染色用于更好地分析胶原纤维特征。
第 7 天，MCG 组的手术伤口扩张，覆盖着痂皮，超出了初始范围。第 21 天，NCG 和 CG 组的伤口完全闭合并上皮化。PCG 和 MCG 组的伤口仍有痂皮残留。NCG 是唯一一组在组织病理学分析中没有脓肿的组。
用提取物治疗的动物的愈合期延长，NCG 组的动物在组织学分析中表现出更好的结果。
