4-氯苯甲酰巴马丁通过 PI3K/Akt 和 NF-κB 信号通路诱导淋巴瘤细胞凋亡和 G2/M 细胞周期阻滞。
4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-kappaB signal pathway in lymphoma cells.
机构信息
Institute of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang 310003, P.R. China.
出版信息
Oncol Rep. 2010 Mar;23(3):709-16. doi: 10.3892/or_00000688.
Berbamine is an herbal compound derived from Berberis amurensis, which is used in Chinese traditional medicine. However, few studies have investigated this anti-tumor effect or the underlying mechanisms of berbamine on lymphoma cells. We investigate the effect, as well as the mechanism of action, of 4-chlorobenzoyl berbamine (BBD9) on Raji, L428, Namalwa and Jurkat lymphoma cells lines. Our findings show that BBD9 inhibits cell proliferation and induces cell apoptosis in lymphoma cell lines as well as G2/M cell cycle arrest through PI3K/Akt and NF-kappaB signaling pathways in a caspase-dependent manner. These results may provide new insights into the treatment of lymphoma.
小檗胺是一种从小檗属植物中提取的中草药化合物，在中国传统医学中被使用。然而，很少有研究调查小檗胺对淋巴瘤细胞的这种抗肿瘤作用或潜在机制。我们研究了 4-氯苯甲酰基小檗胺（BBD9）对 Raji、L428、Namalwa 和 Jurkat 淋巴瘤细胞系的作用及其作用机制。我们的研究结果表明，BBD9 通过 caspase 依赖性方式抑制淋巴瘤细胞系的细胞增殖并诱导细胞凋亡，同时通过 PI3K/Akt 和 NF-κB 信号通路诱导 G2/M 细胞周期阻滞。这些结果可能为淋巴瘤的治疗提供新的思路。
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