制剂参数对卡维地洛超多孔水凝胶自微乳给药系统（SNEDDS）制备的影响。
Effect of formulation parameters on the preparation of superporous hydrogel self-nanoemulsifying drug delivery system (SNEDDS) of carvedilol.
机构信息
Faculty of Pharmacy, Cairo University, Cairo, Egypt.
出版信息
AAPS PharmSciTech. 2010 Mar;11(1):221-5. doi: 10.1208/s12249-009-9359-2. Epub 2010 Feb 3.
Abstract
The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 3(2) factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.
摘要
本研究的目的是制备含有卡维地洛自微乳释药系统的超高孔水凝胶（SPH）。采用 3(2) 因子设计考察了制剂参数（载药过程中使用的 SPH 量和 0.1N HCl 量）的影响。响应面图显示参数对水凝胶溶胀、卡维地洛含量和卡维地洛体外释放有显著影响。生成了回归方程以计算期望的响应。
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