Müller C, Sieber-Ruckstuhl N, Decaro N, Keller S, Quante S, Tschuor F, Wenger M, Reusch C
Klinik für Kleintiermedizin der Universität Zürich.
Schweiz Arch Tierheilkd. 2010 Feb;152(2):63-8. doi: 10.1024/0036-7281.a000015.
Infectious canine hepatitis in 4 Dogs in Switzerland. Four dogs presented with nonspecific symptoms of lethargy, vomiting, diarrhea, fever and weakness. Laboratory results were consistent with hepatopathy and disseminated intravascular coagulation. Three dogs died, one survived. In the three deceased dogs, a diagnosis of infectious canine hepatitis (ICH) was made based on histological findings and positive immunhistochemistry results for canine adenovirus-1 (CAV-1). In the surviving dog, an antemortem diagnosis of ICH was determined via positive polymerase chain reaction results from blood, occular, nasal and preputial discharge as well as from urine. Since the introduction of widespread vaccination, the incidence of CAV-1 infection in dogs is low. However, the disease has not been eradicated and should be considered when clinical signs consistent with ICH are present.
瑞士4只犬感染犬传染性肝炎。4只犬出现嗜睡、呕吐、腹泻、发热和虚弱等非特异性症状。实验室检查结果与肝病和弥散性血管内凝血相符。3只犬死亡，1只存活。在3只死亡犬中，根据组织学检查结果及犬腺病毒1型（CAV-1）免疫组化结果呈阳性，诊断为犬传染性肝炎（ICH）。在存活犬中，通过血液、眼、鼻和包皮排泄物以及尿液的聚合酶链反应结果呈阳性，生前诊断为ICH。自广泛接种疫苗以来，犬感染CAV-1的发生率较低。然而，该疾病尚未根除，当出现与ICH一致的临床症状时应予以考虑。
