Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, LMU Munich, Veterinaerstrasse 13, 80539 Munich, Germany.
Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, An den Tierkliniken 1, 04103 Leipzig, Germany.
Viruses. 2020 Oct 21;12(10):1198. doi: 10.3390/v12101198.
Re-vaccination against canine adenovirus (CAV) is performed in ≤3-year-intervals but their necessity is unknown. The study determined anti-CAV antibodies within 28 days of re-vaccination and factors associated with the absence of antibodies and vaccination response.
Ninety-seven healthy adult dogs (last vaccination ≥12 months) were re-vaccinated with a modified live CAV-2 vaccine. Anti-CAV antibodies were measured before vaccination (day 0), and after re-vaccination (day 7, 28) by virus neutralization. A ≥4-fold titer increase was defined as vaccination response. Fisher's exact test and multivariate regression analysis were performed to determine factors associated with the absence of antibodies and vaccination response.
Totally, 87% of dogs (90/97; 95% CI: 85.61-96.70) had anti-CAV antibodies (≥10) before re-vaccination. Vaccination response was observed in 6% of dogs (6/97; 95% CI: 2.60-13.11). Time since last vaccination (>3-5 years, = 9.375, = 0.020; >5 years, 25.000, = 0.006) was associated with a lack of antibodies. Dogs from urban areas were more likely to respond to vaccination ( = 0.037).
Many dogs had anti-CAV pre-vaccination antibodies, even those with an incomplete vaccination series. Most dogs did not respond to re-vaccination. Based on this study, dogs should be re-vaccinated every 3 years or antibodies should be determined.
犬腺病毒（CAV）的再接种时间间隔不超过 3 年，但再接种的必要性尚不清楚。本研究旨在确定再接种后 28 天内的抗 CAV 抗体以及与无抗体和疫苗接种反应相关的因素。
97 只健康成年犬（最后一次接种≥12 个月）用改良的活 CAV-2 疫苗进行再接种。在接种前（第 0 天）和再接种后（第 7、28 天）通过病毒中和试验测量抗 CAV 抗体。将≥4 倍滴度增加定义为疫苗接种反应。采用 Fisher 精确检验和多变量回归分析确定与无抗体和疫苗接种反应相关的因素。
共有 87%的犬（90/97；95%CI：85.61-96.70）在再接种前具有抗 CAV 抗体（≥10）。6%的犬（6/97；95%CI：2.60-13.11）观察到疫苗接种反应。上次接种时间（>3-5 年， = 9.375， = 0.020；>5 年， 25.000， = 0.006）与无抗体相关。来自城市地区的犬更有可能对疫苗接种产生反应（ = 0.037）。
许多犬在接种前就有抗 CAV 抗体，即使它们的疫苗接种系列不完整。大多数犬对再接种没有反应。根据这项研究，犬应每 3 年再接种一次或应确定抗体。
