Département de Pharmacologie, Université Victor Segalen Bordeaux 2, 33076 Bordeaux, France.
Pharmacoepidemiol Drug Saf. 2010 Mar;19(3):256-65. doi: 10.1002/pds.1912.
To describe the reimbursement databases available in France for pharmacoepidemiological research and their use.
France has a publicly funded health system that systematically covers the population. Within this system, three main insurance schemes provide health services to citizens in France and each have their own reimbursement database. Together these three databases cover almost 97% of the French population (respectively for 54.5, 3.6, and 3.3 million individuals, and a total of 61.4 million individuals). Data in these concern patients, prescribers, all the medical acts reimbursed, prescription and undertaking of laboratory tests (but without results), private hospital data, partial public hospital data and vital status. Their use is regulated but access is free and the data are anonymous. PubMed and Scopus were searched for relevant studies published from January 1988 to June 2009.
110 published studies were included. The topics and the study characteristics were extremely wide-ranging. The studies assessed patterns of drug use, have tested interventions, supported or improved prescribing practices, tested compliance with the French governmental Health guidelines, assessed physicians' prescribing practices and performed economic and cost-effectiveness assessments. The number of articles published increased greatly between 2002 and 2003.
The French reimbursement databases were greatly used over the last 20 years. They can provide data on exposure to drugs and can be used to study patterns of drug utilization although their limitations must be considered.
描述法国用于药物流行病学研究的报销数据库及其用途。
法国拥有一个公共资助的医疗体系，为全国人民提供系统的医疗服务。在这个体系中，有三个主要的保险计划为法国公民提供医疗服务，每个计划都有自己的报销数据库。这三个数据库共同覆盖了法国近 97%的人口（分别为 5450 万人、360 万人和 330 万人，共计 6140 万人）。这些数据库的数据涵盖了患者、处方医生、所有报销的医疗行为、处方和实验室检测的开展（但不包括检测结果）、私立医院数据、部分公立医院数据和人口生命状态。这些数据库的使用受到监管，但访问是免费的，且数据是匿名的。我们在 PubMed 和 Scopus 上检索了 1988 年 1 月至 2009 年 6 月期间发表的相关研究。
共纳入 110 项已发表的研究。研究主题和特征非常广泛。这些研究评估了药物使用模式，测试了干预措施，支持或改进了处方实践，测试了对法国政府卫生指南的遵守情况，评估了医生的处方行为，并进行了经济和成本效益评估。2002 年至 2003 年，发表的文章数量大幅增加。
在过去的 20 年里，法国的报销数据库得到了广泛的应用。它们可以提供关于药物暴露的数据，并可用于研究药物利用模式，但必须考虑到其局限性。
