与混合性结缔组织病相关的视网膜血管病变。
Retinal vasculopathy associated with mixed connective tissue disease.
机构信息
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
出版信息
Ocul Immunol Inflamm. 2010 Jan;18(1):13-5. doi: 10.3109/09273940903402629.
PURPOSE
To report an intractable case of retinal vasculopathy associated with mixed connective tissue disease (MCTD).
DESIGN
Case report.
METHODS
Interventional case report.
RESULTS
A 35-year-old woman presented with decreased visual acuity and multiple retinal hemorrhages and macular edema in her right eye. She had a history of central retinal vein occlusion in the opposite eye and MCTD. Her clinical course deteriorated despite subsequent systemic and intravitreal steroid and immunosuppressant treatments. The retinal vasculopathy involved both artery and vein, causing wide retinal areas of nonperfusion. Her final visual acuity was hand motion.
CONCLUSIONS
MCTD may be associated with bilateral vasculopathy that is refractory to systemic steroid, intravitreal steroid, and immunosuppressant treatment.
目的
报告一例与混合性结缔组织病（MCTD）相关的难治性视网膜血管病变。
设计
病例报告。
方法
介入性病例报告。
结果
一名 35 岁女性因右眼视力下降和多处视网膜出血及黄斑水肿就诊。她曾有对侧视网膜中央静脉阻塞和 MCTD 的病史。尽管随后进行了全身和玻璃体内皮质类固醇和免疫抑制剂治疗，但她的临床病程仍在恶化。视网膜血管病变累及动脉和静脉，导致广泛的视网膜无灌注区。她的最终视力为手动。
结论
MCTD 可能与双侧血管病变有关，对全身皮质类固醇、玻璃体内皮质类固醇和免疫抑制剂治疗均有抗性。
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