LV Prasad Eye Institute, Bhubaneswar 751 024, India.
Ocul Immunol Inflamm. 2010 Jan;18(1):64-5. doi: 10.3109/09273940903315792.
A 48-year-old man, on imatinib therapy for chronic myeloid leukemia, developed bilateral retino-choroiditis. Visual acuity was 20/100 and counting fingers at 2 m in both the right and left eye. Vitreous biopsy (left eye) revealed Toxoplasma gondii genome by polymerase chain reaction. Serum anti-toxoplasma IgG levels were significantly elevated. Blood counts were normal. Bcr-Abl/Abl transcript ratio was 0.016%. He was treated with oral co-trimoxazole, to which corticosteroids in tapering doses were added later. Imatinib therapy was continued. After 6 weeks of therapy, all retinal lesions regressed and vision improved to 20/30 and 20/40 in right and left eyes, respectively.
一位 48 岁男性，因慢性髓性白血病接受伊马替尼治疗，出现双眼视网膜脉络膜炎。右眼和左眼的视力分别为 20/100 和数指 2 米。左眼玻璃体活检通过聚合酶链反应显示刚地弓形虫基因组。血清抗弓形虫 IgG 水平显著升高。血细胞计数正常。Bcr-Abl/Abl 转录物比值为 0.016%。他接受了口服复方磺胺甲噁唑治疗，随后逐渐减少剂量加入皮质类固醇。继续伊马替尼治疗。治疗 6 周后，所有视网膜病变消退，视力分别改善至右眼 20/30 和左眼 20/40。
