Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China.
Cell Biol Int. 2010 Apr 8;34(5):523-30. doi: 10.1042/CBI20090390.
E2 (oestradiol-17beta) is an important hormone that regulates various cell functions including insulin production. hIPCs (human islet-derived precursor cells) are capable of proliferating and differentiating into cells that secrete insulin in response to glucose in vivo and in vitro. However, the effect of E2 on hIPCs is currently unclear. In this study, we found that ERalpha (oestrogen receptor alpha), but not ERbeta, was expressed on hIPCs, and E2 promoted the proliferation and inhibited the differentiation of adult hIPCs. Although fetal hIPCs also express ERalpha, no effect of E2 on the fetal hIPCs was observed, suggesting differing roles of E2 at different stages of pancreatic development. This study indicates that E2 may be one of the key factors that control the turnover of adult pancreatic beta cells by regulating the proliferation and differentiation of adult hIPCs through ERalpha.
E2（雌二醇-17β）是一种重要的激素，可调节各种细胞功能，包括胰岛素的产生。hIPCs（人胰岛衍生前体细胞）能够在体内和体外增殖并分化为响应葡萄糖分泌胰岛素的细胞。然而，E2 对 hIPCs 的影响目前尚不清楚。在这项研究中，我们发现 hIPCs 上表达 ERα（雌激素受体α），而不是 ERβ，E2 促进成年 hIPCs 的增殖并抑制其分化。尽管胎儿 hIPCs 也表达 ERα，但未观察到 E2 对胎儿 hIPCs 的作用，这表明 E2 在胰腺发育的不同阶段发挥不同的作用。这项研究表明，E2 可能是通过 ERα 调节成年 hIPCs 的增殖和分化来控制成年胰腺β细胞更新的关键因素之一。
