Department of Dermatology, Keçiören Research and Training Hospital, 06290 Keçiören, Ankara, Turkey.
Br J Dermatol. 2010 Apr;162(4):798-802. doi: 10.1111/j.1365-2133.2009.09618.x. Epub 2010 Feb 1.
Isotretinoin is an effective treatment for acne vulgaris. However, it has numerous side-effects. It was previously reported that serum growth hormone (GH) levels decreased with isotretinoin treatment.
To analyse whether isotretinoin has any effects on insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP3) and GH levels.
Forty-seven patients aged 21.5 +/- 5.1 years (mean +/- SD) with acne vulgaris were included in this study. Isotretinoin therapy was initiated at a dose of 0.5-0.75 mg kg(-1) daily and then adjusted to 0.88 mg kg(-1) daily as maintenance dosage after 1 month. Screening for biochemical and hormonal parameters was performed just before initiation and after 3 months of isotretinoin treatment.
IGF-1 and IGFBP3 levels decreased significantly after treatment (P < 0.01), while GH levels did not change. Post-treatment, significant increases were seen in aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, triglycerides and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (P < 0.0001) while high-density lipoprotein cholesterol levels were significantly decreased (P < 0.0001).
Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association.
异维 A 酸是治疗寻常痤疮的有效药物。然而，它有许多副作用。此前有报道称，血清生长激素（GH）水平随异维 A 酸治疗而降低。
分析异维 A 酸是否对胰岛素样生长因子-1（IGF-1）、胰岛素样生长因子结合蛋白-3（IGFBP3）和 GH 水平有影响。
本研究纳入 47 名年龄为 21.5 ± 5.1 岁（均值 ± 标准差）的寻常痤疮患者。异维 A 酸治疗起始剂量为 0.5-0.75 mg/kg 每日，1 个月后调整为 0.88 mg/kg 作为维持剂量。在开始治疗前和异维 A 酸治疗 3 个月后进行生化和激素参数筛查。
治疗后 IGF-1 和 IGFBP3 水平显著降低（P < 0.01），而 GH 水平无变化。治疗后，天门冬氨酸氨基转移酶、总胆固醇、低密度脂蛋白胆固醇、甘油三酯和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值显著升高（P < 0.0001），而高密度脂蛋白胆固醇水平显著降低（P < 0.0001）。
异维 A 酸治疗可能对 GH 生理有影响，需要进一步研究以了解这种关联。
