Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Mol Cell. 2010 Jan 15;37(1):5-6. doi: 10.1016/j.molcel.2009.12.028.
In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by HBO1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influences origin usage.
在本期《分子细胞》中,Miotto 和 Struhl(2010)提出,复制许可(即 Mcm2-7 加载到 DNA 上)是由 HBO1 乙酰化复制起始点处的组蛋白 H4 来促进的,这为染色质状态如何影响起始点使用提供了一个分子层面的解释。