Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.
Cancer Cell. 2010 Jan 19;17(1):7-9. doi: 10.1016/j.ccr.2009.12.031.
The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.
近年来，人们对癌症代谢的兴趣日益浓厚，从 IDH 突变的研究进展中可见一斑。自一年多前发现 IDH 突变以来，该领域取得了快速进展。在最近发表在《自然》杂志上的一项研究中，Dang 等人鉴定出 2-羟基戊二酸是肿瘤相关 IDH 突变体的产物，具有潜在的致癌活性。
