Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Cancer Cell. 2010 Jan 19;17(1):9-11. doi: 10.1016/j.ccr.2009.12.030.
Cells exposed to genotoxic insults such as ionizing radiation activate a signaling cascade to repair the damaged DNA. Two recent articles published in Nature show that such genome maintenance requires modifications of tumor suppressor proteins BRCA1 and 53BP1 by the small ubiquitin-like modifier SUMO.
细胞受到如电离辐射等遗传毒性物质的刺激时，会激活信号级联反应来修复受损的 DNA。最近在《自然》杂志上发表的两篇文章表明，这种基因组的维护需要肿瘤抑制蛋白 BRCA1 和 53BP1 通过小泛素样修饰物 SUMO 的修饰。
Zotero 插件