King's College London, Guy's Hospital Campus, St Thomas' Street, London SE1 9RT, UK.
Biochem Soc Trans. 2010 Feb;38(Pt 1):92-7. doi: 10.1042/BST0380092.
Modification by SUMOs (small ubiquitin-related modifiers) is largely transient and considered to alter protein function through altered protein-protein interactions. These modifications are significant regulators of the response to DNA damage in eukaryotic model organisms and SUMOylation affects a large number of proteins in mammalian cells, including several proteins involved in the response to genomic lesions [Golebiowski, Matic, Tatham, Cole, Yin, Nakamura, Cox, Barton, Mann and Hay (2009) Sci. Signaling 2, ra24]. Furthermore, recent work [Morris, Boutell, Keppler, Densham, Weekes, Alamshah, Butler, Galanty, Pangon, Kiuchi, Ng and Solomon (2009) Nature 462, 886-890; Galanty, Belotserkovskaya, Coates, Polo, Miller and Jackson (2009) Nature 462, 935-939] has revealed the involvement of the SUMO cascade in the BRCA1 (breast-cancer susceptibility gene 1) pathway response after DNA damage. The present review examines roles described for the SUMO pathway in the way mammalian cells respond to genotoxic stress.
SUMO（小泛素相关修饰物）的修饰大多是瞬时的，被认为通过改变蛋白质-蛋白质相互作用来改变蛋白质功能。这些修饰是真核模式生物中对 DNA 损伤反应的重要调节剂，SUMOylation 影响哺乳动物细胞中的大量蛋白质，包括参与基因组损伤反应的几种蛋白质[Golebiowski、Matic、Tatham、Cole、Yin、Nakamura、Cox、Barton、Mann 和 Hay（2009）Sci. Signaling 2，ra24]。此外，最近的工作[Morris、Boutell、Keppler、Densham、Weekes、Alamshah、Butler、Galanty、Pangon、Kiuchi、Ng 和 Solomon（2009）Nature 462，886-890；Galanty、Belotserkovskaya、Coates、Polo、Miller 和 Jackson（2009）Nature 462，935-939]揭示了 SUMO 级联在 DNA 损伤后 BRCA1（乳腺癌易感基因 1）途径反应中的参与。本综述检查了 SUMO 途径在哺乳动物细胞应对遗传毒性应激方面的作用。
