The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SA, UK.
Forensic Sci Int Genet. 2010 Feb;4(2):59-61. doi: 10.1016/j.fsigen.2009.08.005. Epub 2009 Sep 2.
A recently published study has used next-gen sequencing technology to resequence two Y chromosomes separated by 13 generations and discovered four single-base differences in approximately 10Mb DNA, suggesting that the Y chromosome euchromatin accumulates around one mutation per generation. Y-SNPs therefore now offer the best resolution of Y haplotypes and promise to distinguish almost every Y chromosome. This work illustrates the promise of current sequencing technology for forensically relevant applications.
最近发表的一项研究使用下一代测序技术对相隔 13 代的两条 Y 染色体进行了重测序，发现了大约 10MbDNA 中的四个单碱基差异，表明 Y 染色体常染色质每代积累约一个突变。因此，Y-SNPs 现在提供了最佳的 Y 单倍型分辨率，并有望区分几乎每一条 Y 染色体。这项工作说明了当前测序技术在法医学相关应用中的前景。
