State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics Chinese Academy of Sciences, Lanzhou 730000, PR China.
J Colloid Interface Sci. 2010 Apr 15;344(2):279-85. doi: 10.1016/j.jcis.2010.01.015. Epub 2010 Jan 18.
High quality water-soluble semiconductor CdSe quantum dots (QDs) were prepared by a phase transfer method, in which amphiphilic oligomers (polymaleic acid aliphatic alcohol ester) was used as surface coating agents. The as-prepared aqueous QDs were high fluorescent and extremely stable. Fourier transform infrared spectroscopy, thermogravimetric analysis, and transmission electron microscopy all indicated that the surfaces of the QDs were coated with amphiphilic oligomers. Alkyl chain length of the amphiphilic oligomers could dramatically affect the phase transfer efficiency. It was found that the use of polymaleic acid n-hexadecanol ester had the best result. A biocompatible test has been carried out and such prepared water-soluble QDs were used to target tumor cells and found that the oligomer-functionalized QDs were excellent fluorescence labels for detecting the human hepatoma cells.
高质量的水溶性半导体 CdSe 量子点（QDs）通过相转移法制备，其中两亲性低聚物（马来酸脂肪醇酯）用作表面涂层剂。所制备的水性 QDs 具有高荧光性和极高的稳定性。傅里叶变换红外光谱、热重分析和透射电子显微镜都表明 QDs 的表面涂覆有两亲性低聚物。两亲性低聚物的烷基链长度会显著影响相转移效率。研究发现，使用马来酸正十六醇酯的效果最好。已经进行了生物相容性测试，并且使用这种制备的水溶性 QDs 来靶向肿瘤细胞，发现寡聚物功能化的 QDs 是检测人肝癌细胞的优异荧光标记物。
