Prince Henry's Institute of Medical Research, 246, Clayton Road, Clayton, VIC 3168, Australia.
Placenta. 2010 Mar;31 Suppl:S99-104. doi: 10.1016/j.placenta.2009.12.027. Epub 2010 Feb 2.
Blastocyst implantation into the endometrium is critical for the establishment of pregnancy and is tightly regulated by factors within the blastocyst-endometrial micro-environment. Implantation is a continuum involving blastocyst adhesion to the endometrial epithelium followed by trophoblast penetration of the epithelium. The trophoblast proliferates and invades through the endometrium, with a subpopulation acting to remodel the spiral arteries. Trophoblast-endometrial interactions in humans involve carefully orchestrated temporal and spatial alterations in factors that are critical for pregnancy success. Emerging evidence suggests important roles for locally produced cytokines including interleukin 11 and leukemia inhibitory factor in the various stages of implantation. This review focuses on the role of these cytokines in trophoblast-endometrial interactions during the establishment of human pregnancy.
囊胚植入子宫内膜对于妊娠的建立至关重要，并且受到囊胚-子宫内膜微环境中各种因素的严格调控。着床是一个连续的过程，包括囊胚黏附在内皮上，然后滋养层穿透上皮。滋养层增殖并通过子宫内膜侵入，其中一个亚群作用于重塑螺旋动脉。人类滋养层-子宫内膜的相互作用涉及到对妊娠成功至关重要的因素的精心协调的时空改变。新出现的证据表明，局部产生的细胞因子，包括白细胞介素 11 和白血病抑制因子，在着床的各个阶段都起着重要作用。这篇综述重点介绍了这些细胞因子在人类妊娠建立过程中对滋养层-子宫内膜相互作用的作用。
