Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Epilepsy Res. 2010 May;89(2-3):238-45. doi: 10.1016/j.eplepsyres.2010.01.007. Epub 2010 Feb 2.
Certain music has been shown to improve mental function, leading to what is known as the Mozart effect. This study measured the impact of Mozart's Sonata for two pianos in D major, K.448, on different epileptic foci of epileptiform discharge in Taiwanese children (n=58) with seizure disorders and investigated the characteristics of the musical stimulus presented that resulted in epileptiform discharge reduction.
We examined the relationship between the number of discharges with the foci of epileptiform discharge (n=6), sleep state, gender, and mentality. A continuous electroencephalogram was recorded before, during and after exposure to Mozart's Sonata for two pianos in D major, K.448 (piano K.448), and the frequencies of discharges were compared. The study was repeated a week later using digitally computerized string version of the same musical stimulus (string K.448), in patients who responded to piano K.448 with the largest reduction in interictal discharges (n=11).
Interictal discharges were reduced in most (81.0%) patients and varied greatly (33.10+/-28.33%) as they listened to the piano K.448 (more fundamental tones and lower harmonics). Patients with generalized or central discharge showed the most improvement. In most patients (76.1%), the decrease in epileptiform discharges continued after the music ended. The state of wakefulness, gender and mentality did not affect the results. Although the string K.448 had a larger number of higher harmonics in the spectrogram analysis, the discharges were not reduced at all when listening to this music.
These results suggest that listening to Mozart K.448 for two pianos reduced epileptiform discharges in children with epilepsy. This study suggests that it is possible to reduce the number of epileptiform discharges in some patients by optimizing the fundamental tones and minimizing the higher frequency harmonics.
某些音乐已被证明可以改善心理功能，从而产生所谓的莫扎特效应。本研究测量了莫扎特的 D 大调双钢琴奏鸣曲，K.448 对台湾患有癫痫发作障碍的癫痫样放电的不同癫痫灶的影响，并研究了导致癫痫样放电减少的音乐刺激的特征。
我们检查了放电数量与癫痫灶放电的关系（n=6）、睡眠状态、性别和智力。在暴露于 D 大调双钢琴莫扎特奏鸣曲 K.448（钢琴 K.448）之前、期间和之后记录连续脑电图，并比较放电频率。在对钢琴 K.448 反应最大的患者中（n=11），在一周后使用相同音乐刺激的数字计算机化弦乐版本（弦乐 K.448）重复该研究。
大多数患者（81.0%）的发作间期放电减少，差异很大（33.10+/-28.33%），因为他们听钢琴 K.448（更多基频和更低的泛音）。具有全身性或中央放电的患者改善最大。在大多数患者（76.1%）中，音乐结束后癫痫样放电的减少仍在继续。清醒状态、性别和智力均不影响结果。尽管弦乐 K.448 在频谱分析中有更多的高频泛音，但在听这种音乐时，放电根本没有减少。
这些结果表明，听莫扎特 K.448 双钢琴可以减少癫痫儿童的癫痫样放电。本研究表明，通过优化基频和最小化高频泛音，有可能减少一些患者的癫痫样放电次数。
