Morris肝癌3924A中修饰的环核苷酸系统有利于环鸟苷酸效应的表达。

Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect.

作者信息

Shoji M, Morris H P, Davis C W, Brackett N L, Kuo J F

出版信息

Biochim Biophys Acta. 1977 Dec 22;500(2):419-24. doi: 10.1016/0304-4165(77)90032-0.

PMID:201299

Abstract

Modifications in the cyclic nucleotide systems favoring the expression of cyclic GMP effects were found to occur in the transplanted fast-growing Morris hepatoma 3924A. These included: (a) a decreased level of cyclic GMP phosphodiesterase and an increased level of cyclic AMP phosphodiesterase; (b) a disproportionately increased level of cylic GMP-dependent protein kinase relative to that of cyclic AMP-dependent protein kinase; (c) a disproportionately increased level of stimulatory modulator of cyclic AMP-dependent protein kinase relative to that of inhibitory modulator of cyclic AMP-dependent protein kinase; and (d) an increased level of phosphoprotein phosphatase.

摘要

在移植的快速生长的莫里斯肝癌3924A中发现了有利于环鸟苷酸（cGMP）效应表达的环核苷酸系统修饰。这些修饰包括：（a）环鸟苷酸磷酸二酯酶水平降低，环腺苷酸（cAMP）磷酸二酯酶水平升高；（b）相对于环腺苷酸依赖性蛋白激酶，环鸟苷酸依赖性蛋白激酶水平不成比例地升高；（c）相对于环腺苷酸依赖性蛋白激酶的抑制性调节剂，环腺苷酸依赖性蛋白激酶的刺激性调节剂水平不成比例地升高；以及（d）磷蛋白磷酸酶水平升高。