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心脏死亡后的控制性器官捐献:急诊科的潜在供者。

Controlled organ donation after cardiac death: potential donors in the emergency department.

机构信息

Departments of Anaesthesia and Critical Care, Royal Infirmary, Edinburgh, Scotland.

出版信息

Transplantation. 2010 May 15;89(9):1149-53. doi: 10.1097/TP.0b013e3181d2bff4.

Abstract

BACKGROUND.: The continuing shortfall of organs for transplantation has increased the use of donation after cardiac death (DCD). We hypothesized that some patients who undergo tracheal intubation in the emergency department (ED) and who are assessed for, but not admitted to, critical care might have potential for controlled DCD. METHODS.: We identified all patients who underwent tracheal intubation in the ED between 2004 and 2008 and studied their records to identify those not admitted to an intensive care unit. We reviewed the notes of patients extubated in the ED to ascertain the diagnosis, management, outcome, and potential exclusion criteria for controlled DCD. RESULTS.: One thousand three hundred seventy-four patients had tracheal intubation performed in the ED; 1053 received anesthetic drugs to assist intubation. Three hundred seventy-five patients were not admitted to intensive care unit; 235 died during resuscitation in the ED. Of the 49 patients extubated in the ED to allow terminal care, 26 were older than 70 years and 18 had comorbidities precluding organ donation. Fourteen patients could have been considered for DCD, but in eight, the time from extubation to death exceeded 2 hr. Thus, six patients might have been missed as potential controlled DCD from the ED in this 5-year period. CONCLUSIONS.: Identification of potential donors after cardiac death in the ED with appropriate use of critical care for selected patients may contribute to reducing the shortfall of organs for transplantation, although numbers are likely to be small. This area remains controversial and requires further informed discussion between emergency and critical care doctors and transplant teams.

摘要

背景

由于可供移植的器官持续短缺,心脏死亡后的捐献(DCD)使用有所增加。我们假设,在急诊科(ED)接受气管插管并接受评估但未收入重症监护病房的某些患者可能具有潜在的控制性 DCD 可能性。

方法

我们确定了 2004 年至 2008 年期间在 ED 接受气管插管的所有患者,并研究了他们的病历,以确定未收入重症监护病房的患者。我们回顾了 ED 拔管患者的病历,以确定诊断、治疗、结果和控制性 DCD 的潜在排除标准。

结果

1374 名患者在 ED 进行了气管插管;1053 名患者接受了麻醉药物以协助插管。375 名患者未收入重症监护病房;235 名在 ED 复苏过程中死亡。在 ED 拔管以进行临终护理的 49 名患者中,26 名年龄大于 70 岁,18 名患有排除器官捐献的合并症。有 14 名患者可以考虑进行 DCD,但在 8 名患者中,从拔管到死亡的时间超过 2 小时。因此,在这 5 年期间,可能有 6 名患者被错过作为 ED 潜在的控制性 DCD。

结论

在 ED 通过适当使用重症监护对选定患者进行心脏死亡后潜在供体的识别可能有助于减少可供移植的器官短缺,尽管数量可能很小。该领域仍存在争议,需要急诊和重症监护医生以及移植团队之间进一步进行知情讨论。

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