Pleacher Kristine M, Roach Elizabeth S, Van der Werf Willem, Antommaria Armand H M, Bratton Susan L
Department of Pediatrics, Division of Pediatric Critical Care, University of Utah, Salt Lake City, UT, USA.
Pediatr Crit Care Med. 2009 Mar;10(2):166-70. doi: 10.1097/PCC.0b013e318194800b.
To determine the impact of a pediatric donation after cardiac death (DCD) program on organ donation.
Retrospective case series.
A free-standing children's hospital.
All ventilated pediatric intensive care unit patients who died between September 1, 2005 and April 30, 2007.
Institution of a DCD program.
Data collected included clinical features, medical eligibility and consent for organ donation, as well as outcome for donation among eligible patients. One hundred ten patients who died in the pediatric intensive care unit and were treated with mechanical ventilation immediately before death were identified. Thirty-one patients met exclusion criteria, 26 patients were not referred, and 53 patients were evaluated for potential DCD by the organ procurement agency. The majority of patients had anoxia or trauma as their primary diagnosis. Family members initiated discussions regarding donation in 17% of evaluations. Sixty-eight percent of patients were deemed medically ineligible by the organ procurement agency. Of the 17 medically eligible patients, consent for donation was given in 9 cases (53%). Of these, 7 patients (41%) successfully donated; accounting for 37% of organ donors during the study period. Two families gave consent for donation which did not occur; one child did not die within the required time period and one could not be matched with any recipients.
Although a small percentage of dying patients are eligible for and will undergo DCD, such a program can markedly increase the number of organ donors at a children's hospital.
确定儿童心脏死亡后器官捐献(DCD)项目对器官捐献的影响。
回顾性病例系列研究。
一家独立的儿童医院。
2005年9月1日至2007年4月30日期间在儿科重症监护病房死亡的所有接受机械通气的患儿。
实施DCD项目。
收集的数据包括临床特征、器官捐献的医学适宜性和同意情况,以及符合条件患者的捐献结果。确定了110例在儿科重症监护病房死亡且在死亡前立即接受机械通气治疗的患者。31例患者符合排除标准,26例患者未被转诊,53例患者由器官获取机构评估是否适合进行DCD。大多数患者的主要诊断为缺氧或创伤。在17%的评估中,家庭成员发起了关于捐献的讨论。器官获取机构认为68%的患者不符合医学标准。在17例符合医学标准的患者中,9例(53%)给予了捐献同意。其中,7例患者(41%)成功捐献;占研究期间器官捐献者的37%。两个家庭给予了捐献同意,但未成功进行;一个孩子未在规定时间内死亡,另一个孩子无法找到匹配的受者。
尽管只有一小部分濒死患者符合条件并将接受DCD,但这样一个项目可以显著增加儿童医院的器官捐献者数量。