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[狂犬病免疫的下一步是什么?]

[What is next in antirabies immunization?].

作者信息

Haasová L, Matouch O, Jílek D, Král V, Richter J, Svedjda J

机构信息

Infekcní oddĕlení KUNZ-KNSP, Ustí nad Labem.

出版信息

Cas Lek Cesk. 1991 Jan 11;130(2):54-6.

PMID:2013068
Abstract

The authors compare the geometrical means of titres of specific antirabic antibodies in a group of subjects immunized by the intradermal route with vaccine from a tissue culture of human diploid cell (Rabivac Behring, FRG) and in groups of subjects immunized by the subcutaneous route with the vaccine Vnukovo SAD-32 (USSR), using a short and long immunization pattern resp. The group with intradermal administration had higher geometrical mean values of antibody titres than the age-matched group immunized by the subcutaneous vaccine Vnukovo. The low mean titres and incidence of zero values of antirabic antibodies in age groups above 50 years is alarming.

摘要

作者比较了一组通过皮内途径用来自人二倍体细胞组织培养的疫苗(德国贝林公司的狂犬病疫苗)免疫的受试者,以及分别采用短期和长期免疫方案通过皮下途径用Vnukovo SAD - 32疫苗(苏联)免疫的受试者群体中特异性抗狂犬病抗体滴度的几何平均值。皮内给药组的抗体滴度几何平均值高于年龄匹配的通过皮下接种Vnukovo疫苗免疫的组。50岁以上年龄组抗狂犬病抗体的平均滴度较低以及零值发生率令人担忧。

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