Twelves C J, Ash C M, Miles D W, Thomas D G, Souhami R L
Department of Oncology, University College and Middlesex Hospital Medical School, London, UK.
Cancer Chemother Pharmacol. 1991;27(6):481-3. doi: 10.1007/BF00685164.
A total of 15 patients with relapsed high-grade glioma were treated with carboplatin (400 mg/m2) or iproplatin (300 mg/m2). All had received previous radiotherapy, and 12 had previously undergone chemotherapy. One of the ten patients treated with carboplatin and one of the five treated with iproplatin achieved a partial remission as determined by repeat computerised tomographic (CT) scan. Myelosuppression was considerable, as three patients developed grade IV neurotoxicity, which was fatal in one case. Although carboplatin and iproplatin showed activity against malignant glioma, the study was closed because of unacceptable toxicity.
共有15例复发性高级别胶质瘤患者接受了卡铂（400mg/m²）或异丙铂（300mg/m²）治疗。所有患者此前均接受过放疗，其中12例曾接受过化疗。接受卡铂治疗的10例患者中有1例、接受异丙铂治疗的5例患者中有1例经重复计算机断层扫描（CT）检查确定达到部分缓解。骨髓抑制相当严重，有3例患者出现IV级神经毒性，其中1例死亡。尽管卡铂和异丙铂对恶性胶质瘤显示出活性，但由于毒性不可接受，该研究提前结束。
