Meyer Otto, Meyer Sandra, Kressig Reto W
Akutgeriatrie, Universitätsspital Basel.
Ther Umsch. 2010 Feb;67(2):69-73. doi: 10.1024/0040-5930/a000013.
Delirium is a clinical diagnosis, which is based on observed disturbances of consciousness and cognitive dysfunction. Associated neuropsychiatric and psychomotoric symptoms are common. Many elderly delirious patients are hypoactive, manifesting a passive demeanor, reduced activity and, in extreme cases, stupor and coma. Delirium has an acute onset and a fluctuating course. It is usually reversible. It is crucial to examine cognitive functions among elderly hospitalized patients, since advanced age and preexisting dementia are important risk factors for the development of delirium. In patients with suspected delirium there should follow a further diagnostic approach with specific tests, such as the Confusion Assessment Method (CAM), a diagnostic tool which has a high sensitivity and specifity. Delirium often develops during the course of hospitalization, so repeated screening and cognitive testing is needed. Predisposing factors need to be identified and treated. The cause of delirium is often multifactorial and heterogeneous. Symptoms might be subtle, and clinicians frequently under-recognize delirium, so that it is often diagnosed late in its course. Especially in the elderly delirium can be the only symptom of an acute and severe illness. The typical clinical findings of this illness can be missing. The clinical examination and careful use of diagnostic tools is therefore essential in the identification and treatment of delirium.
谵妄是一种临床诊断,基于观察到的意识障碍和认知功能障碍。相关的神经精神症状和精神运动症状很常见。许多老年谵妄患者活动减少,表现出被动的行为举止、活动量降低,在极端情况下会出现木僵和昏迷。谵妄起病急,病程波动。通常是可逆的。对老年住院患者进行认知功能检查至关重要,因为高龄和既往存在的痴呆是谵妄发生的重要危险因素。对于疑似谵妄的患者,应采用进一步的诊断方法并进行特定检查,如谵妄评估方法(CAM),这是一种具有高敏感性和特异性的诊断工具。谵妄常在住院期间发生,因此需要反复进行筛查和认知测试。需要识别并治疗诱发因素。谵妄的病因通常是多因素且异质性的。症状可能很细微,临床医生常常对谵妄认识不足,以至于往往在病程后期才做出诊断。尤其是在老年人中,谵妄可能是急性重症疾病的唯一症状。这种疾病的典型临床特征可能不存在。因此,临床检查和谨慎使用诊断工具对于谵妄的识别和治疗至关重要。