Am J Hematol. 2010 Mar;85(3):213-5. doi: 10.1002/ajh.21608.
The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,115 Connecticut women. Although we did not find strong evidence that the genetic polymorphisms modify the relationship between alcohol consumption and risk of NHL, we identified significant interactions for multiple GSTs and NATs and alcohol intake among persons with DLBCL. Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.
本研究旨在探讨细胞色素 P450(CYPs)、谷胱甘肽 S-转移酶(GSTs)和 N-乙酰基转移酶(NATs)基因的遗传多态性是否会改变人群为基础的病例对照研究中饮酒与非霍奇金淋巴瘤(NHL)风险之间的关系,该研究包括 1115 名康涅狄格州妇女。尽管我们没有发现遗传多态性会显著改变饮酒与 NHL 风险之间的关系的有力证据,但我们在弥漫性大 B 细胞淋巴瘤(DLBCL)患者中发现了 GSTs 和 NATs 与酒精摄入之间存在显著的相互作用。我们的研究结果支持在更大的弥漫性大 B 细胞淋巴瘤研究人群中对基因-环境相互作用进行研究。