谷胱甘肽S-转移酶和细胞色素P450s的基因多态性、吸烟与非霍奇金淋巴瘤风险
Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma.
作者信息
Kilfoy Briseis A, Zheng Tongzhang, Lan Qing, Han Xuesong, Qin Qin, Rothman Nathaniel, Holford Theodore, Zhang Yawei
机构信息
Department of Environmental Health Sciences, School of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06520-8034, USA.
出版信息
Am J Hematol. 2009 May;84(5):279-82. doi: 10.1002/ajh.21386.
We investigated variation in glutathione S-transferases (GSTs) and cytochrome P450s (CYPs), and smoking in a population-based case-control study of NHL including 1,115 women. Although risk of NHL was not altered by variant polymorphisms in GSTs or CYPs, it was significantly changed for DLBCL when considered in conjunction with smoking behavior, though only in nonsmokers. An increased risk of DLBCL in nonsmokers was associated with the variant G allele for GSTP1 (OR = 1.6, 95% CI 1.0-2.3) and CYP1A1 (OR = 2.4; 95% CI 1.0-5.7), but a decreased risk for the variant G allele for CYP1B1 (OR = 0.6, 95% CI 0.4-1.0). Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.
在一项纳入1115名女性的基于人群的非霍奇金淋巴瘤病例对照研究中，我们调查了谷胱甘肽S-转移酶（GSTs）和细胞色素P450（CYPs）的变异情况以及吸烟情况。尽管GSTs或CYPs中的变异多态性并未改变非霍奇金淋巴瘤的风险，但当结合吸烟行为考虑时，弥漫性大B细胞淋巴瘤（DLBCL）的风险发生了显著变化，不过仅在不吸烟者中如此。不吸烟者中DLBCL风险增加与GSTP1的变异G等位基因（比值比[OR]=1.6，95%置信区间[CI]1.0 - 2.3）和CYP1A1（OR = 2.4；95% CI 1.0 - 5.7）相关，但CYP1B1的变异G等位基因风险降低（OR = 0.6，95% CI 0.4 - 1.0）。我们的结果支持在更大的弥漫性大B细胞淋巴瘤研究人群中对基因-环境相互作用进行研究。
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