First Department of Propaedeutic Medicine, Athens University Medical School, Laiko General Hospital, 33 Lakonias Street, Athens, Greece.
Diabetes Metab Res Rev. 2010 Feb;26(2):121-7. doi: 10.1002/dmrr.1063.
Metabolic syndrome (MetS) is common and is associated with increased cardiovascular morbidity and mortality. Recent prospective studies suggested that MetS is associated with increased risk of heart failure. In the present cross-sectional study, we examined the association between left ventricular myocardial performance with MetS.
A total of 550 non-diabetic subjects, 275 without MetS and 275 with MetS, matched for gender, age and body mass index and free of clinically apparent macrovascular disease were studied. MetS was diagnosed using the NCEP-ATP III criteria. Left ventricular myocardial performance was assessed using the Tei index.
Both men and women with MetS had higher values of the Tei index, indicating worse myocardial performance, in comparison with those without MetS (p < 0.001). Participants with a cluster of more components of the MetS had higher Tei index values than those with fewer components of the MetS. In addition, among normotensive subjects, those with MetS had significantly higher Tei index values than subjects without MetS. Multivariate linear regression analysis, after adjustment for age and body mass index, demonstrated that MetS status and from the individual components of the MetS, high fasting blood glucose levels, higher blood pressure, low high density lipoprotein levels and high waist circumference were associated with worse myocardial performance.
MetS is associated with subclinical myocardial dysfunction in both men and women. Strategies to reduce the cardiovascular burden and the risk of heart failure associated with MetS should aim at prevention of the MetS and its related conditions.
代谢综合征（MetS）较为常见，与心血管发病率和死亡率的增加相关。最近的前瞻性研究表明，MetS 与心力衰竭风险增加相关。在本横断面研究中，我们研究了 MetS 与左心室心肌性能之间的关系。
共纳入 550 例非糖尿病患者，275 例无 MetS，275 例有 MetS，两组在性别、年龄和体重指数方面相匹配，且无明显的大血管疾病。MetS 采用 NCEP-ATP III 标准进行诊断。采用 Tei 指数评估左心室心肌性能。
与无 MetS 的患者相比，有 MetS 的男性和女性的 Tei 指数更高，表明心肌性能更差（p<0.001）。具有更多 MetS 成分的患者的 Tei 指数值高于具有较少 MetS 成分的患者。此外，在血压正常的患者中，有 MetS 的患者的 Tei 指数值明显高于无 MetS 的患者。在调整年龄和体重指数后，多元线性回归分析显示，MetS 状态以及 MetS 的各个成分（空腹血糖升高、血压升高、高密度脂蛋白水平降低和腰围增粗）与心肌性能较差相关。
MetS 与男性和女性的亚临床心肌功能障碍相关。旨在降低与 MetS 相关的心血管负担和心力衰竭风险的策略应针对 MetS 及其相关疾病进行预防。
