Lin C-C, Liu C-S, Li T-C, Chen C-C, Li C-I, Lin W-Y
China Medical University Hospital, Taichung, Taiwan.
Eur J Clin Invest. 2007 Oct;37(10):783-90. doi: 10.1111/j.1365-2362.2007.01865.x.
Microalbuminuria and the metabolic syndrome (MetS) have both been linked to chronic kidney disease and cardiovascular disease. This study investigated the association between urinary albumin-to-creatinine ratio (ACR) and MetS and its components.
A total of 2311 subjects aged 40 years and over were recruited in 2004 in a metropolitan city in Taiwan. The biochemical indices, such as fasting glucose levels, urinary albumin, urinary creatinine and anthropometric indices, were measured. We defined microalbuminuria as a urinary ACR ranging from 30 to 300 mg g(-1) creatinine. MetS was defined using the American Heart Association and the National Heart, Lung and Blood Institute (AHA/NHLBI) and the International Diabetes Federation (IDF) definitions. The relationship between MetS and microalbuminuria was examined using multiple logistical regression analysis.
Subjects with microalbuminuria had higher age, body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose, triglycerides, total cholesterol (TCHOL)/high-density lipoprotein cholesterol (HDL-C) ratio, prevalence of diabetes mellitus and hypertension and lower HDL-C than subjects with normoalbuminuria. After adjusting for age and BMI, microalbuminuria was associated with the individual components of MetS, except in central obesity in women and elevated fasting glucose in men. After adjusting for age, BMI, smoking and alcohol consumption status, multiple logistical regressions revealed that microalbuminuria is strongly associated with MetS in both genders and according to both definitions. The odds ratio of having MetS using the AHA/NHLBI and IDF definition was 1.76 (1.16-2.67) and 1.73 (1.06-2.83) in men and 2.19 (1.38-3.50) and 2.09 (1.24-3.51) in women, respectively.
Microalbuminuria was strongly associated with MetS and its components. There is an increased likelihood of having MetS if subjects have microalbuminuria.
微量白蛋白尿和代谢综合征（MetS）均与慢性肾脏病和心血管疾病相关。本研究调查了尿白蛋白与肌酐比值（ACR）和MetS及其组分之间的关联。
2004年在台湾某大城市招募了2311名40岁及以上的受试者。测量了生化指标，如空腹血糖水平、尿白蛋白、尿肌酐和人体测量指标。我们将微量白蛋白尿定义为尿ACR范围为30至300mg/g（-1）肌酐。MetS采用美国心脏协会和美国国立心肺血液研究所（AHA/NHLBI）以及国际糖尿病联盟（IDF）的定义。使用多元逻辑回归分析检查MetS与微量白蛋白尿之间的关系。
与正常白蛋白尿受试者相比，微量白蛋白尿受试者年龄更大、体重指数（BMI）、腰围、血压、空腹血糖、甘油三酯、总胆固醇（TCHOL）/高密度脂蛋白胆固醇（HDL-C）比值更高，糖尿病和高血压患病率更高，HDL-C更低。在调整年龄和BMI后，微量白蛋白尿与MetS的各个组分相关，但女性的中心性肥胖和男性的空腹血糖升高除外。在调整年龄、BMI、吸烟和饮酒状况后，多元逻辑回归显示，根据两种定义，微量白蛋白尿在男女中均与MetS密切相关。使用AHA/NHLBI和IDF定义患MetS的比值比在男性中分别为1.76（1.16 - 2.67）和1.73（1.06 - 2.83），在女性中分别为2.19（1.38 - 3.50）和2.09（1.24 - 3.51）。
微量白蛋白尿与MetS及其组分密切相关。如果受试者有微量白蛋白尿，则患MetS的可能性增加。
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