Soh Chai Hoon, Lam Yulin
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
J Comb Chem. 2010 Mar 8;12(2):286-91. doi: 10.1021/cc900176x.
A microwave-assisted solid-phase synthesis of 2-(benzylthio)imidazo[1,2a]pyrimidin-5-ones has been developed. Using microwave irradiation, the reaction time was significantly reduced from a few days to 80 min. A representative set of 10 2-(benzylthio)-6,7-substituted-imidazo[1,2a]pyrimidin-5-ones was prepared. These compounds were subsequently N-alkylated and formylated in good yields.
已开发出一种微波辅助的2-(苄硫基)咪唑并[1,2 - a]嘧啶 - 5 - 酮的固相合成方法。使用微波辐射，反应时间从几天显著缩短至80分钟。制备了一组代表性的10种2-(苄硫基)-6,7 - 取代的咪唑并[1,2 - a]嘧啶 - 5 - 酮。这些化合物随后进行N - 烷基化和甲酰化反应，产率良好。
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