Department of Chemistry, University of Delhi, Delhi 110 007, India.
J Agric Food Chem. 2010 Mar 10;58(5):3056-61. doi: 10.1021/jf904144e.
Thirty-one substituted hydrazones of nalidixic acid hydrazide were synthesized and characterized by spectral techniques. These compounds were evaluated for various biological activities, namely, fungicidal, insecticidal, and nitrification inhibitory activities. The antifungal activity was evaluated against five pathogenic fungi, namely, Rhizoctonia bataticola , Sclerotium rolfsii , Rhizoctonia solani , Fusarium oxysporum , and Alternaria porii . They showed maximum inihibition against A. porii with ED(50) = 34.2-151.3 microg/mL. The activity was comparable to that of a commercial fungicide, hexaconazole (ED(50) = 25.4 microg/mL). They were also screened for insecticidal activity against third-instar larvae of Spodoptera litura and adults of Callosobruchus maculatus and Tribollium castaneum . Most of them showed 70-100% mortality against S. litura through feeding method at 0.1% dose. These compounds were not found to be effective nitrification inhibitors.
合成了 31 种萘啶酸酰肼的取代腙，并通过光谱技术进行了表征。这些化合物被评估了各种生物活性，即杀菌、杀虫和硝化抑制活性。抗真菌活性评估了针对五种病原菌，即茄病镰刀菌、菌核盘菌、立枯丝核菌、尖孢镰刀菌和疣孢漆斑菌。它们对 A. porii 的抑制作用最大，ED(50) = 34.2-151.3 μg/mL。其活性与商业杀菌剂戊唑醇（ED(50) = 25.4 μg/mL）相当。它们还被筛选了对三化螟幼虫和绿豆象成虫和赤拟谷盗成虫的杀虫活性。通过 0.1%剂量的摄食法，大多数化合物对 S. litura 表现出 70-100%的死亡率。这些化合物没有被发现是有效的硝化抑制剂。
