Haque Syed K, Siddiqui Mashiat U, Islam Najmul, Moin Shagufta
Department of Biochemistry, Aligarh Muslim University, U.P., India.
Hypertens Pregnancy. 2010 Jan;29(1):69-81. doi: 10.3109/10641950902849868.
Preeclampsia can have significant impact on health of both mother and fetus. It had been proposed that maternal endothelial cell dysfunction is the key event resulting in the diverse clinical manifestations of preeclampsia and evidence has since accumulated. Research in recent times is indicative of the role of oxidative stress in the endothelial cell dysfunction. Preeclampsia is more common in first pregnancy and studies have further shown an increase in risk of preeclampsia with maternal age. The aim of this study was to explore the status of oxidative stress in higher age-group preeclamptic and normal pregnant mother. The study included 20 normal pregnant women and 60 preeclamptic women. They were allocated into 4 subgroups between ages 20-25, 26-30, 31-35, and 36-40. Erythrocytes were analyzed for the following antioxidant enzymes, i.e., glutathione peroxidase, superoxide dismutase and catalase.Lipid peroxidation product, malondialdehyde, was analyzed to determine oxidative stress. The results showed an increase in oxidative stress, and high magnitude suppression/decrease in antioxidant enzymes activities in erythrocytes with increase in age groups in both preeclamptic and normal pregnant women. This indicates that an increase in the risk of preeclampsia with maternal age could be due to an increase in oxidative stress with age. This further attests to the role of oxidative stress in preeclampsia.
子痫前期可对母亲和胎儿的健康产生重大影响。有人提出，母体内皮细胞功能障碍是导致子痫前期多种临床表现的关键事件，此后证据不断积累。近年来的研究表明氧化应激在内皮细胞功能障碍中起作用。子痫前期在初产妇中更为常见，研究进一步表明，子痫前期的风险会随着母亲年龄的增加而升高。本研究的目的是探讨高龄子痫前期孕妇和正常孕妇的氧化应激状况。该研究纳入了20名正常孕妇和60名子痫前期孕妇。她们被分为20 - 25岁、26 - 30岁、31 - 35岁和36 - 40岁这4个亚组。对红细胞进行了以下抗氧化酶的分析，即谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶。分析脂质过氧化产物丙二醛以确定氧化应激情况。结果显示，子痫前期孕妇和正常孕妇中，随着年龄组的增加，氧化应激增加，红细胞中抗氧化酶活性受到高度抑制/降低。这表明子痫前期风险随母亲年龄增加可能是由于氧化应激随年龄增加所致。这进一步证明了氧化应激在子痫前期中的作用。
