Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, Bethesda, MD 20892, USA.
Am J Addict. 2010 Jan-Feb;19(1):96-100. doi: 10.1111/j.1521-0391.2009.00010.x.
Today substance dependence is one of the major public health problems in the world with millions of people abusing legal and illegal drugs. In addition, almost one-third of the world's population suffers with one or more infections. Both drugs of abuse and infections are associated with serious medical and health consequences, some of which may be exacerbated by the occurrence of pharmacokinetic and/or pharmacodynamic interactions between medications used in the treatment of these conditions when they co-occur. This review briefly discusses issues surrounding clinical management related to drug interactions experienced by substance abusing patients. The emphasis of this paper is on the research needed to further study the extent, nature, and underlying molecular/genetic mechanism(s) of interactions between drugs of abuse, medications used in the treatment of drug addiction, and co-occurring infections.
如今，物质依赖是世界上主要的公共卫生问题之一，数百万人滥用合法和非法药物。此外，几乎世界上三分之一的人口患有一种或多种传染病。滥用药物和感染都与严重的医疗和健康后果有关，其中一些后果可能因治疗这些疾病的药物在同时发生时发生药代动力学和/或药效学相互作用而加剧。这篇综述简要讨论了与滥用药物患者药物相互作用相关的临床管理问题。本文的重点是需要进一步研究的研究，以研究滥用药物、治疗药物成瘾的药物和同时发生的感染之间相互作用的程度、性质和潜在的分子/遗传机制。
