血小板衍生生长因子-AA 及其受体α 在肾母细胞瘤中的表达及其预后价值。

Expression and prognostic value of platelet-derived growth factor-AA and its receptor α in nephroblastoma.

机构信息

Department of Urology, Menoufiya University, Shebin El-Kom, Menoufiya, Egypt.

出版信息

BJU Int. 2010 Nov;106(9):1389-93. doi: 10.1111/j.1464-410X.2010.09211.x.

DOI:10.1111/j.1464-410X.2010.09211.x

PMID:20132200

Abstract

OBJECTIVE

To investigate the potential role of platelet-derived growth factor-AA (PDGF-AA) and the PDGF-α receptor as prognostic markers in Wilms' tumour.

PATIENTS AND METHODS

The expression of PDGF-AA and PDGF-α were investigated using immunohistochemical analysis of 62 Wilms' tumours. Patients were treated with chemotherapeutic agents before surgery and had a mean follow-up of 6.4 years.

RESULTS

PDGF-AA and PDGF-α were expressed by the mesenchymal tissue of the normal kidney and mainly detected in the epithelial component of Wilms' tumour. Immunoreactive tumour epithelium cells were found in 50% and 55% for PDGF-AA and PDGF-α, respectively. The epithelial expression of both PDGF-AA and PDGF-α correlated with pathological stage. Univariate analysis showed that epithelial PDGF-AA and PDGF-α receptor expression were indicative of clinical progression. In a multivariate analysis, PDGF-α protein expression by epithelial cells was an independent prognostic marker of a favourable prognosis.

CONCLUSIONS

Expression of both PDGF-AA and PDGF-α in the epithelial part of Wilms' tumour correlated with tumour stage and clinical progression. Our data suggest that both PDGF-AA and PDGF-α receptor expression are related to prognosis.

摘要

目的

探讨血小板衍生生长因子-AA（PDGF-AA）和 PDGF-α受体在威尔姆斯瘤（Wilms' tumour）中的潜在作用及其作为预后标志物的价值。

方法

采用免疫组织化学分析方法检测了 62 例威尔姆斯瘤中的 PDGF-AA 和 PDGF-α的表达。患者在手术前接受了化疗药物治疗，平均随访 6.4 年。

结果

PDGF-AA 和 PDGF-α均在正常肾脏的间质组织中表达，主要在威尔姆斯瘤的上皮成分中检测到。PDGF-AA 和 PDGF-α的免疫反应性肿瘤上皮细胞的阳性率分别为 50%和 55%。两种 PDGF 的上皮表达均与病理分期相关。单因素分析显示，上皮 PDGF-AA 和 PDGF-α受体表达与临床进展相关。多因素分析显示，上皮细胞 PDGF-α蛋白表达是预后良好的独立预后标志物。