Department of Applied Chemistry, Faculty of Chemistry, University of The Basque Country, San Sebastian 20018, Spain.
Mol Microbiol. 2010 Mar;75(5):1314-24. doi: 10.1111/j.1365-2958.2010.07063.x. Epub 2009 Feb 1.
Fungi are capable of generating diverse cell types through developmental processes that stem from hyphae, acting as pluripotent cells. The formation of mitospores on emergence of hyphae to the air involves the participation of transcription factors, which co-ordinate the genesis of new cell types, eventually leading to spore formation. In this investigation, we show that bZip transcription factor FlbB, which has been attributed to participate in transducing the aerial stimulus signal, activates the expression of c-Myb transcription factor FlbD. Both factors then jointly activate brlA, a C(2)H(2) zinc finger transcription factor, which plays a central role in spore formation. This sequence of regulatory events resembles developmental control mechanisms involving c-Myb and bZip counterparts in metazoans and plants.
真菌能够通过源自菌丝的发育过程产生多种细胞类型，充当多能细胞。菌丝向空气中伸出时形成分生孢子，涉及转录因子的参与，这些转录因子协调新细胞类型的发生，最终导致孢子形成。在这项研究中，我们表明，bZip 转录因子 FlbB 被认为参与传递空中刺激信号，激活 c-Myb 转录因子 FlbD 的表达。这两个因子然后共同激活 brlA，一种 C(2)H(2)锌指转录因子，在孢子形成中起核心作用。这一系列调控事件类似于涉及后生动物和植物中的 c-Myb 和 bZip 对应物的发育控制机制。
