Lentino J R, Augustinsky J B, Weber T M, Pachucki C T
Medical Service, Edward Hines Jr. VA Hospital, Hines, Ill.
Chemotherapy. 1991;37(1):70-6. doi: 10.1159/000238836.
We evaluated the safety and efficacy of ofloxacin administered both by the intravenous route and orally in 26 men with serious skin and soft tissue infection. Twenty-one patients completed antimicrobial therapy and were fully evaluable. Of these, 18 were judged to be cured, while 3 failed therapy either during or within 2 weeks after completion of therapy. Overall, Staphylococcus aureus was the most commonly isolated pathogen and was found to be susceptible to ofloxacin in 12 of 14 patients. Two patients, 1 with a tolerant isolate of S. aureus, the other patient with a resistant isolate of S. aureus, responded clinically to ofloxacin therapy; a third patient with an initially ofloxacin-sensitive isolate failed therapy, and on subsequent culture an ofloxacin-resistant S. aureus was isolated. Ofloxacin was well tolerated and efficacious in the treatment of skin and soft tissue infections including those caused by staphylococci and streptococci.
我们评估了静脉注射和口服氧氟沙星对26例严重皮肤及软组织感染男性患者的安全性和有效性。21例患者完成了抗菌治疗且可进行全面评估。其中，18例被判定治愈，3例在治疗期间或治疗结束后2周内治疗失败。总体而言，金黄色葡萄球菌是最常分离出的病原体，14例患者中有12例的分离株对氧氟沙星敏感。2例患者，1例为耐氧氟沙星金黄色葡萄球菌分离株，另1例为耐药金黄色葡萄球菌分离株，对氧氟沙星治疗有临床反应；第3例患者最初的分离株对氧氟沙星敏感，但治疗失败，后续培养分离出耐氧氟沙星金黄色葡萄球菌。氧氟沙星耐受性良好，对包括葡萄球菌和链球菌引起的皮肤及软组织感染有效。
