Comtois Philippe, Potse Mark, Vinet Alain
Institut de cardiologie de Montréal, Institut de génie biomédical, Université de Montréal, Montréal, Canada.
Med Sci (Paris). 2010 Jan;26(1):57-64. doi: 10.1051/medsci/201026157.
Models of cardiac electrical activity cover a wide range of spatial scales, from the genesis of the ionic currents in individual cardiomyocytes to the generation of electrocardiograms on the torso. The level of detail that is appropriate and practicable depends on the problem investigated and the scope of the computations that are required. We briefly present three examples of modelling: the dynamics of the entrainment of a single cell, the impact of fibrosis on electrical propagation in a piece of tissue and the generation of ECG in human. In each case, the methods, results and limitations are discussed.
心脏电活动模型涵盖了广泛的空间尺度，从单个心肌细胞中离子电流的产生到躯干上心电图的生成。合适且可行的细节程度取决于所研究的问题以及所需计算的范围。我们简要介绍三个建模示例：单个细胞的夹带动力学、纤维化对一块组织中电传播的影响以及人体心电图的生成。在每种情况下，都会讨论方法、结果和局限性。
