de Bakker Jacques M T, van Rijen Harold M V
Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, The Netherlands.
J Cardiovasc Electrophysiol. 2006 May;17(5):567-73. doi: 10.1111/j.1540-8167.2006.00367.x.
Although cardiac muscle has been considered as an electrical syncytium for a long time, several aspects of conduction of the electrical impulse in the heart could not be explained by a continuous approach. Even the simple anisotropic nature of cardiac muscle gives rise to a number of conduction characteristics that contradicts with results from continuous models. It is, however, evident that cardiac conduction must be discontinuous in nature owing to recurrent resistive discontinuities caused by the cellular interconnections. In this review, the role of discontinuities at the cellular and macroscopic level on cardiac propagation will be discussed.
尽管很长一段时间以来心肌都被视为一个电连接体,但心脏中电冲动传导的几个方面无法用连续模型来解释。即使是心肌简单的各向异性特性也会产生一些与连续模型结果相矛盾的传导特征。然而,很明显,由于细胞间连接导致的反复电阻不连续性,心脏传导本质上必然是不连续的。在这篇综述中,将讨论细胞和宏观层面的不连续性在心脏电传导中的作用。