Max-Planck Institute for Experimental Medicine at the Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Maona, USA.
Eur J Pharmacol. 2010 Apr 25;632(1-3):1-6. doi: 10.1016/j.ejphar.2010.01.027. Epub 2010 Feb 2.
Corticotropin-releasing factor (CRF), a 41 amino acid peptide, was discovered as a key signal in mediating neuroendocrine, autonomic, and behavioral responses to stress. It was revealed later that there exist additional CRF-like peptides, termed urocortins. The CRF receptor subtype 1 (CRF1 receptor) is predominant in the brain whereas subtype 2 (CRF2 receptor) is highly expressed in the brain and the heart. Both centrally and peripherally administered CRF and urocortins produce significant hemodynamic effects via activation of CRF receptors in the brain and the heart. CRF and urocortins are important neural and cardioactive hormones, and are potentially useful therapy for heart failure.
促肾上腺皮质释放因子（CRF）是一种 41 个氨基酸的肽，作为介导神经内分泌、自主和行为对应激反应的关键信号而被发现。后来发现还有其他的 CRF 样肽，称为尿皮质素。CRF 受体亚型 1（CRF1 受体）在大脑中占优势，而亚型 2（CRF2 受体）在大脑和心脏中高度表达。CRF 和尿皮质素通过在大脑和心脏中激活 CRF 受体，中枢和外周给药都能产生显著的血液动力学效应。CRF 和尿皮质素是重要的神经和心脏活性激素，对心力衰竭可能是有用的治疗方法。
