Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Texas Children's Liver Center, Baylor College of Medicine, Pediatrics/Liver Center, One Baylor Plaza, Houston, TX 77030, USA.
J Hepatol. 2010 Mar;52(3):455-62. doi: 10.1016/j.jhep.2009.12.002. Epub 2009 Dec 24.
A joint EASL/AASLD Monothematic Conference on 'Nuclear Receptors and Liver Disease' was held from February 27th to March 1st, 2009, in Vienna, Austria, to discuss the latest advances at the forefront of basic and clinical nuclear receptor research and its potential implications for liver diseases. This article reports the highlights of the conference and summarizes the main conclusions emphasizing the relevance for clinical and experimental hepatology. The confluence of nuclear receptors as central transcriptional regulators, acting as sensors and adaptors to many of the small molecules present in the intracellular milieu of all the cells of the liver, provides a current framework to address a broader physiological understanding of the liver. The next stage will be the design and testing of safe and effective therapeutics.
2009 年 2 月 27 日至 3 月 1 日，在奥地利维也纳举行了一次 EASL/AASLD 联合专题会议，讨论基础和临床核受体研究前沿的最新进展及其对肝脏疾病的潜在影响。本文报道了会议的重点，并总结了主要结论，强调了其与临床和实验肝脏病学的相关性。核受体作为中央转录调节剂的融合，作为许多存在于肝脏所有细胞细胞内环境中的小分子的传感器和适配器，为更广泛的肝脏生理学理解提供了一个当前的框架。下一阶段将是安全有效的治疗药物的设计和测试。
