Paniagua Correa C, García Alonso P, Balsa Bretón M A, Mariana Monguía A, Penín González F J, Pey Illera C
Servicio de Medicina Nuclear, Hospital Universitario de Getafe, Getafe, Madrid, España.
Rev Esp Med Nucl. 2010 Mar-Apr;29(2):57-62. doi: 10.1016/j.remn.2009.12.008. Epub 2010 Feb 4.
To perform a descriptive analysis of the clinical and diagnostic implications of (123)I-IBZM SPECT in the patients studied in our center for movement disorders suggestive of Parkinson-Plus Disease (PP).
(123)I-IBZM SPECT was performed in 46 patients referred from the movement disorders consultation due to suspicion of PP. According to their symptoms, they were distributed into 3 groups: 35 patients had atypical symptoms (AS) for Parkinson's Disease, 2 showed no response to standard therapy (NR) and 9 presented both factors (AS, NR). The results of SPECT were only assessed qualitatively.
The (123)I-IBZM supported the diagnosis of PP in 15(42.9%) out of the 35 patients with AS. The (123)I-IBZM was pathological in one of the two NR patients. Regarding the third group of patients (AS+NR), the (123)I-IBZM was pathological in 6 cases (66.7%). In 95.7% of our sample (44 patients), AS with or without NR was the main factor leading to suspicion of PP and the (123)I-IBZM was altered in only 47.7% (22 patients). Of these 22 cases, the final diagnosis was PP (with high positive predictive value) in 20(91%).
The study with (123)I-IBZM is useful in the clinical practice because it provides objective diagnostic information with implications for the treatment and prognosis of patients with suspicion of PP.
对我院针对疑似帕金森叠加综合征（PP）的运动障碍患者进行的（123）I-碘苄胍单光子发射计算机断层扫描（SPECT）的临床及诊断意义进行描述性分析。
对46例因疑似PP从运动障碍门诊转诊而来的患者进行了（123）I-碘苄胍SPECT检查。根据症状，将他们分为3组：35例患者有帕金森病的非典型症状（AS），2例对标准治疗无反应（NR），9例同时具备这两个因素（AS、NR）。SPECT结果仅进行定性评估。
在35例有AS的患者中，（123）I-碘苄胍支持PP诊断的有15例（42.9%）。在2例NR患者中，有1例（123）I-碘苄胍结果呈病理性。对于第三组患者（AS+NR），（123）I-碘苄胍有6例（66.7%）呈病理性。在我们的样本中，95.7%（44例患者）的AS伴或不伴NR是导致疑似PP的主要因素，而（123）I-碘苄胍结果异常的仅占47.7%（22例患者）。在这22例中，最终诊断为PP（阳性预测值高）的有20例（91%）。
（123）I-碘苄胍研究在临床实践中有用，因为它能提供客观的诊断信息，对疑似PP患者的治疗和预后有重要意义。
