ADF/cofilin：细胞生物学中的一个功能节点。
ADF/cofilin: a functional node in cell biology.
机构信息
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA.
出版信息
Trends Cell Biol. 2010 Apr;20(4):187-95. doi: 10.1016/j.tcb.2010.01.001. Epub 2010 Feb 3.
Abstract
Recent findings have significantly expanded our understanding of the regulation of actin-depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these well-established regulators of actin dynamics have on cell biology. In this review we discuss new aspects of previously documented regulation, such as phosphorylation, but also cover novel recently established modes of regulation and functions of ADF (also known as destrin)/cofilin. We now understand that their activity responds to a vast array of inputs far greater than previously appreciated and that these proteins not only feed back to the crucially important dynamics of actin, but also to apoptosis cascades, phospholipid metabolism, and gene expression. We argue that this ability to respond to physiological changes by modulating those same changes makes the ADF/cofilin protein family a homeostatic regulator or 'functional node' in cell biology.
摘要
最近的研究发现极大地扩展了我们对肌动蛋白解聚因子 (ADF)/丝切蛋白蛋白调控的理解，以及这些成熟的肌动蛋白动力学调节剂对细胞生物学的深远影响。在这篇综述中，我们讨论了以前记录的调控的新方面，如磷酸化，但也涵盖了 ADF（也称为 destrin）/丝切蛋白的新的最近确立的调控模式和功能。我们现在知道，它们的活性响应于比以前理解的广泛得多的大量输入，这些蛋白质不仅反馈到肌动蛋白的至关重要的动力学，而且反馈到细胞凋亡级联、磷脂代谢和基因表达。我们认为，通过调节这些相同的变化来响应生理变化的这种能力使 ADF/cofilin 蛋白家族成为细胞生物学中的稳态调节剂或“功能节点”。
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