School of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia.
Cardiovasc Pathol. 2011 Mar-Apr;20(2):114-23. doi: 10.1016/j.carpath.2010.01.001. Epub 2010 Feb 4.
Abdominal aortic aneurysm is a common degenerative disorder associated with sudden death due to aortic rupture. Current therapy is limited to open surgical repair of the aorta or endovascular placement of covered stents to exclude the abdominal aortic aneurysm from the circulation. A number of different animal models have been developed in order to study abdominal aortic aneurysm in an effort to advance current management deficiencies. Large animal models have been mostly used to assist in developing novel methods to surgically treat abdominal aortic aneurysms. Small animal models, particularly those developed in rodents, have been employed to further the understanding of the mechanisms involved in abdominal aortic aneurysm in order to identify potential new medical treatments. It is expected that findings from these animal models will contribute importantly to new treatments for human abdominal aortic aneurysm. This review explores the animal models which are used in abdominal aortic aneurysm research and highlights their advantages and disadvantages.
腹主动脉瘤是一种常见的退行性疾病，可因主动脉破裂而导致突然死亡。目前的治疗方法仅限于开放手术修复主动脉或血管内放置覆膜支架，以将腹主动脉瘤从循环中排除。为了研究腹主动脉瘤，已经开发了许多不同的动物模型，以努力改善当前的管理缺陷。大型动物模型主要用于协助开发新的手术治疗腹主动脉瘤的方法。小型动物模型，特别是在啮齿动物中开发的模型，已被用于进一步了解腹主动脉瘤中涉及的机制，以确定潜在的新的医学治疗方法。预计这些动物模型的研究结果将对人类腹主动脉瘤的新治疗方法做出重要贡献。本综述探讨了用于腹主动脉瘤研究的动物模型，并强调了它们的优缺点。
