Istanbul Kultur University, Science and Letters Faculty, Department of Physics, 34156 Istanbul, Turkey.
Spectrochim Acta A Mol Biomol Spectrosc. 2010 Apr;75(4):1304-7. doi: 10.1016/j.saa.2009.12.069. Epub 2010 Jan 6.
The adsorption of isoniazid (INH) on sepiolite, loughlinite (natural Na-sepiolite) and palygorskite from Anatolia was investigated by FT-IR spectroscopy. Experimental results indicated that INH molecules, adsorbed on sepiolite-palygorskite group of clays, are coordinated to surface hydroxyls by H-bonding interaction through the pyridine ring nitrogen lone pairs. Moreover, some of the adsorbed INH molecules may enter the interior channels of the sepiolite-palygorskite structure and involve H-bonding interaction with zeolitic water. Some intensity and frequency changes in the OH stretching band of surface hydroxyls (Si-OH) of the INH-treated sepiolite and loughlinite were observed. However, this band is found to be less affected by the adsorption of isoniazid in the case of palygorskite, probably because the surface Si-OH groups in palygorskite appear to be less abundant than in sepiolite or loughlinite.
采用傅里叶变换红外光谱法研究了异烟肼（INH）在土耳其分离蛋白、软皂石（天然 Na-分离蛋白）和坡缕石上的吸附。实验结果表明，INH 分子通过吡啶环氮孤对与表面羟基通过氢键相互作用吸附在分离蛋白-坡缕石组粘土上。此外，一些吸附的 INH 分子可能进入分离蛋白-坡缕石结构的内部通道，并与沸石水发生氢键相互作用。在 INH 处理过的分离蛋白和软皂石中，表面羟基（Si-OH）的 OH 伸缩带的一些强度和频率发生了变化。然而，在坡缕石的情况下，发现这个带受异烟肼吸附的影响较小，这可能是因为坡缕石中的表面 Si-OH 基团比分离蛋白或软皂石中的要少。
