Eukaryotic DNA primase. Abortive synthesis of oligoadenylates.
作者信息
Podust V N, Vladimirova O V, Manakova E N, Lavrik O I
机构信息
Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
出版信息
FEBS Lett. 1991 Mar 25;280(2):281-3. doi: 10.1016/0014-5793(91)80312-q.
PMID:2013323
Abstract
Calf thymus DNA polymerase alpha-primase, human placenta DNA polymerase alpha-primase and human placenta DNA primase synthesized oligoriboadenylates of a preferred length of 2-10 nucleotides and multimeric oligoribonucleotides of a modal length of about 10 monomers on a poly(dT) template. The dimer and trimer were the prevalent products of the polymerization reaction. However, only the oligonucleotides from heptamers to decamers were elongated efficiently by DNA polymerase alpha.
摘要
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